ABSTRACT
Objective Many trials have been conducted with regard to the relative benefits of prophylactic anti-emetic interventions given alone or in combination, yet the results remain unknown. This study reviewed the efficacy of a single prophylactic dose of dexamethasone on postoperative nausea or vomiting [PONV] after abdominal hysterectomy. Methods In a prospective study of 100 women undergoing total abdominal hysterectomy [TAH] under general anesthesia, the dexamethasone group [n = 50] received a single dose [8 mg] immediately after the operation, and the saline group [n = 50] received a dose of saline as a placebo, in addition to conventional management. The incidence of nausea, vomiting, the need for an anti-emetic and patient satisfaction with the management of PONV were evaluated during the first 24 postoperative hours. Results The overall frequency of nausea during the initial postoperative 24 in the dexamethasone and saline groups were 12% and 18%, respectively, and vomiting was 10% and 16%, respectively [P = 0.001]. However, there was a lower need for a rescue anti-emetic drugs in the dexamethasone group [18% vs 24%], but it was not statistically significant [P = 0.06]. Conclusion The results of this study indicate that a single prophylactic dose of dexamethasone after an operation can reduce postoperative nauseaandvomiting
ABSTRACT
The purpose of this study was to compare the success rates of 70 patients from the same database, each with an ectopic pregnancy [EP] that was treated with either the single- or multi-dose methotrexate [MTX] protocols for unruptured EPs. This study was a blinded, randomized clinical trial. Treatment protocols were either single- [50 mg/m[2] dose MTX or multi-dose [1 mg/kg MTX + 0.1 mg/kg folinic acid]. There were 35 cases in each group. The outcome was measured by adverse events, resolution of pregnancy without surgical treatment, success rate of MTX treatment, and fertility outcome in each group. With the single-dose protocol, response to treatment was considered successful in 29 [82.9%] patients; in the multi-dose protocol 31 [88.6%] responded to treatment. The difference between success rates in the groups was not statistically significant [p=0.587]. In the single dose group, 2 [5.7%] patients and in the multi-dose group, 6 [17.2%] patients had complications [p=0.28]. Of the 14 patients in the single-dose group. Clinical pregnancy occurred in 9 [75%] whereas clinical pregnancy occurred in 3 [25%] patients from the multi-dose group. Infertility was seen in 4 [33.3%] patients in the single-dose group and in 8 [66.7%] in the multi-dose group. We believe that the single-dose MTX protocol could be as successful as multi-dose MTX for the treatment of EP. It is effective, cost-effective, and associated with better fertility outcomes than the multi-dose MTX protocol [Registration Number: IRCT201112178435N1].
ABSTRACT
The objective of this study was evaluation of excessive pregnancy weight gain effect in non-diabetic women with normal pre-pregnancy BMI on macrosomia of neonate. In a descriptive cross-sectional study, neonate weighs of all term pregnancy in non-diabetic women with normal pre-pregnancy BMI delivered from 2002 to 2004 in Shaheed Sadoughi Hospital in Yazd, were evaluated. Compared with mothers with normal pregnancy weight gain, the risk of macrosomia in offsprings was significantly elevated in women who had excess weight gain. The odds ratio [OR] was 3.3 [95% confidence interval [CI] = 2.2 - 5.1, P = 0.0001]. Given the complications associated with delivering large babies, women may benefit from not gaining excess weight in pregnancy
Subject(s)
Humans , Female , Weight Gain , Pregnancy , Body Mass Index , Infant, Newborn , Cross-Sectional StudiesABSTRACT
To compare the safety and efficacy of fluconazole 150 mg single dose and intra-vaginal clotrimazole 200 mg per day for six days in the treatment of the acute episode of vulvovaginal candidiasis [VVC]. In a prospective study, 142 patients with acute clinical and mycological confirmed VVC were enrolled and divided randomly in two groups. 70 patients received intra-vaginal tablet [200 mg] daily for seven days, whereas 72 patients received single dose oral fluconazole [150 mg]. Second and third visits were done for all patients seven days and one month after treatment and the clinical and mycological outcomes evaluated. The analysis performed using SPSS statistical software [version 15]. At the second visit, 61 patients [84.7%] were cured clinically [inflammation and discharge] and 58 patients [80.5%] mycologically in fluconazole group and 60 patients [83.3%] were cured clinically and 49 patients [70%] mycologically in clotrimazole group [P = 0.01]. At the third visit, only one patient in fluconazole group and 17 patients in clotrimazole group had clinical sign of VVC [P = 0.001]. Oral fluconazole single dose seems to be a valid and promising therapy to cure acute signs and symptoms of VVC
ABSTRACT
Maternal position during the second stage of labor can be considered to be an intervention in the natural course of labor. This study aimed to establish the effect of sitting versus lithotomic position on duration of second stage of labor, preneal truma and neonatal outcome. This clinical trial study was done on 110 term nuliparuse women with normal conducte of labor in second stage, which divided randomly in sitting position, [n=55] and lithotomic position [n=55] in teaching hospital in Yazd, Iran during 2005-06. Duration of second stage, Perinea trauma and first 5 minutes APGAR evaluated and compared in two groups. Data analyzed by SPSS-11.5 with T student and Chi square tests. P<0.05 was significant. Duration of second stage of labor was 34 and 42 minutes in sitting and lithotomic position respectively [P<0.05]. Perinea damage was seen in 15 [27.3%] and 24 [43.6%] women of sitting and lithotomic position respectively [P<0.05]. No significant difference existed between the groups in neonatal first 5 minutes APGAR. This study showed that sitting position reduce second stage duration and perinea trauma versus lithotomic position